Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin in the eye: implications for glaucoma.

Per O Lundmark1, S R Pandi-Perumal, V Srinivasan

  • 1Department of Optometry and Vision Sciences, Buskerud University College, Kongsberg, 3601 Ko, Norway.

Experimental Eye Research
|December 19, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Surgical Resection of Horizontal Extraocular Muscles Disrupt Ocular Proprioceptors?

Clinical ophthalmology (Auckland, N.Z.)·2023
Same author

Comparison of Short-Term Effects of Treatment of Accommodative Infacility with Low Plus Addition in Single Vision Rx or Vision Therapy: A Pilot Study.

Clinical optometry·2022
Same author

Prevalence and Predictors of Ocular Complications in Obstructive Sleep Apnea Patients: A Cross-sectional Case-control Study.

The open respiratory medicine journal·2020
Same author

Efficacy of vitamin D replacement therapy in restless legs syndrome: a randomized control trial.

Sleep & breathing = Schlaf & Atmung·2018
Same author

Survey of referrals and medical reports in optometric practices in Norway: midterm findings from a 3-year prospective Internet-based study.

Clinical optometry·2018
Same author

Hepatitis B Vaccination Rate in Patients with Diabetes: Assessment of Racial and Socioeconomic Disparity.

International journal of clinical endocrinology and metabolism·2017
Same journal

Comparative analyses of the differentiation and stemness status of corneal epithelial cell lines in varying culture conditions.

Experimental eye research·2026
Same journal

Corneal deformation mapping and FE-based strain analysis via digital image correlation: Biomechanical changes after CXL and laser refractive surgery.

Experimental eye research·2026
Same journal

Tanshinone IIA inhibits choroidal neovascularization and restores outer blood-retinal barrier function in Vldlr knockout mice.

Experimental eye research·2026
Same journal

Understanding the ocular accumulation of mefuparib and its N-dealkylation metabolite: Pharmacokinetics, melanin affinity, and cellular disposition.

Experimental eye research·2026
Same journal

Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets.

Experimental eye research·2026
Same journal

Middle-wavelength green ambient light attenuates lens-induced myopia progression and is associated with suppression of the Wnt/β-catenin signaling pathway in guinea pigs.

Experimental eye research·2026
See all related articles

Melatonin, a potent antioxidant, is synthesized in the eye and may protect against ocular diseases. Its antioxidant and antinitridergic properties show promise for treating glaucoma.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Chronobiology

Background:

  • Melatonin is synthesized in the retina of humans and various animal species.
  • Circadian oscillators regulate retinal melatonin synthesis, and melatonin receptors are present in ocular tissues.
  • Melatonin acts as a potent antioxidant, scavenging free radicals in ocular tissues.

Purpose of the Study:

  • To explore the potential protective roles of melatonin against various ocular disorders.
  • To investigate the role of melatonin in the pathogenesis and potential treatment of glaucoma.

Main Methods:

  • Review of existing data on melatonin synthesis, receptors, and antioxidant properties in ocular tissues.
  • Analysis of the role of free radicals, glutamate, and nitric oxide in glaucoma pathogenesis.

Related Experiment Videos

  • Evaluation of melatonin's antioxidant and antinitridergic effects in the context of ocular health.

    • Main Results:

    • Melatonin's antioxidant capabilities suggest protective effects against glaucoma, age-related macular degeneration, retinopathy of prematurity, photo-keratitis, and cataracts.
    • Beyond intraocular pressure, factors like elevated glutamate and altered nitric oxide metabolism contribute to glaucoma.
    • Melatonin demonstrates significant antioxidant and antinitridergic properties relevant to ocular health.

    Conclusions:

    • Melatonin's antioxidant and antinitridergic actions position it as a potential therapeutic agent for ocular conditions.
    • Melatonin shows particular promise in the management and treatment of glaucoma.
    • Further research into melatonin's role in ocular health is warranted.