Related Experiment Video
Updated: Jul 18, 2026

Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH
Published on: September 20, 2020
FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1
Toru Fukuda1, Kazuhiro Kanomata, Junya Nojima
1Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Yamane 1397-1, Hidaka-shi, Saitama 350-1241, Japan.
Abstract:
Fibroblast growth factor 23 (FGF23) is a key humoral factor in phosphate homeostasis and skeletogenesis, though the nature of its intracellular signaling is still unclear. Recently, Egr-1, a zinc-finger transcription factor, was identified as an immediate early response gene of FGF23 in the kidney. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1. Both isoforms of NAB2 induced by FGF23 were localized in the nucleus and suppressed the transcriptional activity of Egr-1. A negative feedback loop established by Egr-1 and NAB2 may thus be involved in mediating the physiological effects of FGF23.
Related Concept Videos
Co-activators and Co-repressors
Co-activators and Co-repressors
NF-kB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
TGF - β Signaling Pathway
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
General Transcription Factors
