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Non-heart-beating kidney transplantation: 6-year outcomes.

A O Sanni1, C H Wilson, H Wyrley-Birch

  • 1Regional Liver/Renal Transplant Unit, Freeman Hospital, Newcastle upon Tyne, United Kingdom. aliu_oladipupo@yahoo.com

Transplantation Proceedings
|December 19, 2006
PubMed
Summary

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Non-heart-beating donor kidneys (NHBD) offer comparable long-term graft and recipient survival rates to heart-beating donor kidneys (HBD). Initial graft function is lower with NHBD kidneys but becomes comparable by 6 years post-transplant.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Organ Donation

Background:

  • Increasing demand for kidney transplants necessitates expanding the donor pool.
  • Non-heart-beating donor (NHBD) kidneys are utilized to address the shortage of cadaveric heart-beating donor (HBD) kidneys.

Purpose of the Study:

  • To evaluate and compare the long-term outcomes of renal transplantation using NHBD versus HBD kidneys.
  • To assess graft survival, recipient survival, and graft function quality between the two donor types.

Main Methods:

  • Retrospective comparison of the first 100 NHBD kidney transplants with consecutive cadaveric HBD kidney transplants.
  • Analysis of graft survival, recipient survival, and mean glomerular filtration rates (GFR) at 6 years post-transplantation.

Related Experiment Videos

Main Results:

  • Recipient survival at 6 years was 83% for NHBD and 89% for HBD (P = .22).
  • Graft survival at 6 years was 80% for NHBD and 87% for HBD (P = .19).
  • Mean GFR was significantly lower in the NHBD group up to 3 months post-discharge (41 vs 47, P = .007) but comparable by 6 years (43 vs 46, P = .55).

Conclusions:

  • NHBD kidneys provide comparable long-term graft and recipient survival rates to HBD kidneys.
  • While initial graft function may be reduced, NHBD kidneys achieve comparable function by 6 years post-transplant.
  • NHBD kidneys represent a viable option for expanding the donor pool in renal transplantation.