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Renal graft function after prolonged agonal time in non-heart-beating donors
S Sohrabi1, A Navarro, C Wilson
1Freeman Hospital, Liver and Renal Transplant Unit, Newcastle upon Tyne, UK. so_sor@yahoo.co.uk
Transplantation Proceedings
|December 19, 2006
Summary
Kidney transplantation utilizes organs from non-heart-beating (NHB) donors. Prolonging the agonal period in Maastricht category III donors did not significantly impact intermediate kidney graft function at 12 and 24 months.
Area of Science:
- Nephrology
- Transplantation Surgery
- Organ Donation
Background:
- Increasing organ demand for kidney transplantation necessitates utilizing non-heart-beating (NHB) donors.
- Concerns exist regarding potential organ quality deterioration with prolonged donor agonal periods.
Purpose of the Study:
- To evaluate the impact of extended agonal periods on kidney graft quality from Maastricht category III donors.
Main Methods:
- Retrospective audit of 40 kidney transplants from 29 Maastricht category III donors (1998-2004).
- Donors categorized by agonal time: <5 hours versus >5 hours.
- Kidney graft function assessed by mean glomerular filtration rate (GFR) at 12 and 24 months, matched for donor and recipient factors.
Main Results:
- Mean GFR at 12 months: 43.8 +/- 4.4 (<5 hours) vs. 49.8 +/- 5.8 (>5 hours), P = .24.
- Mean GFR at 24 months: 46.83 +/- 8.99 (<5 hours) vs. 37.67 +/- 3.85 (>5 hours), P = .24.
- No statistically significant difference in intermediate graft function between groups.
Conclusions:
- Intermediate kidney graft function is comparable between donors with prolonged (>5 hours) and shorter (<5 hours) agonal times.
- Further long-term outcome data is pending.
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