Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates.

Lab on a chip·2026
Same author

Mesoscale Modeling of Hydrogels Under Frictional Shear Stress.

Macromolecules·2026
Same author

Growth order of stiff and soft domains in gels controls morphology.

iScience·2026
Same author

Computer Simulations of Soft Responsive Gels with Embedded Regular Arrangements of Stiff Fibers.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Chemical signaling in reaction networks generates corresponding mechanical impulses.

PNAS nexus·2025
Same author

A functionally complete logic gate in a soft photoresponsive hydrogel.

Nature communications·2025

Related Experiment Video

Updated: Jul 18, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
11:53

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

Modeling the release of nanoparticles from mobile microcapsules.

Rolf Verberg1, Alexander Alexeev, Anna C Balazs

  • 1Chemical Engineering Department, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

The Journal of Chemical Physics
|December 21, 2006
PubMed
Summary

This study simulates nanoparticle release from microcapsules and their adsorption onto channel walls. Findings offer guidelines for optimizing microcapsule carriers for targeted nanoparticle delivery.

More Related Videos

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Related Experiment Videos

Last Updated: Jul 18, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
11:53

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers

Published on: July 21, 2017

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
12:00

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Published on: February 24, 2016

Area of Science:

  • Computational fluid dynamics
  • Nanoparticle dynamics
  • Microfluidics

Background:

  • Microcapsules are used for targeted delivery, but their release dynamics and particle adsorption are complex.
  • Understanding fluid-structure interactions is crucial for optimizing delivery efficiency.

Purpose of the Study:

  • To develop a computational model for simulating nanoparticle release from a moving microcapsule and subsequent adsorption onto channel walls.
  • To investigate the influence of microcapsule elasticity, capsule-surface adhesion, and nanoparticle diffusion on adsorption.
  • To identify parameters for maximizing nanoparticle adsorption for efficient targeted delivery.

Main Methods:

  • Integrated lattice spring model (micromechanics) and lattice Boltzmann model (fluid dynamics).
  • Simulated fluid-structure interactions including capsule shell, encapsulated fluid, and host solution.
  • Modeled nanoparticle motion using Brownian dynamics simulation under a pressure gradient.

Main Results:

  • Demonstrated that microcapsule elasticity significantly impacts nanoparticle deposition.
  • Identified key parameters influencing the amount of adsorbed nanoparticles.
  • Quantified the relationship between capsule properties, adhesion, diffusion, and adsorption efficiency.

Conclusions:

  • The developed computational approach accurately simulates nanoparticle release and adsorption.
  • Findings provide crucial insights into optimizing microcapsule-based delivery systems.
  • Offers practical guidelines for enhancing targeted nanoparticle delivery efficiency.