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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

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Published on: June 26, 2020

Fourth human parechovirus serotype.

Kimberley S M Benschop¹, Janke Schinkel, Manon E Luken

¹Academic Medical Center, Amsterdam, the Netherlands. k.s.benschop@amc.uva.nl

Emerging Infectious Diseases

|December 21, 2006

Summary

A new human parechovirus (HPeV) type, K251176-02, was discovered in a neonate. This novel HPeV strain represents a distinct fourth serotype, requiring updated diagnostic and neutralization strategies.

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Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

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Published on: December 21, 2019

Area of Science:

Virology
Infectious Diseases
Molecular Biology

Background:

Human parechoviruses (HPeV) are known human picornaviruses.
Existing HPeV serotypes 1-3 are associated with various clinical manifestations.

Observation:

A novel HPeV strain, designated K251176-02, was isolated from a febrile neonate.
Genomic analysis confirmed K251176-02 as a distinct HPeV genotype.

Findings:

K251176-02 demonstrated resistance to neutralization by antibodies against known HPeV serotypes 1-3.
This immunological distinctiveness supports its classification as a new HPeV serotype.

Implications:

The identification of a fourth HPeV serotype necessitates updates to diagnostic assays.
This finding impacts our understanding of HPeV diversity and pathogenesis.
Further research is needed to assess the clinical significance and epidemiology of this new serotype.