ICD-9 codes and surveillance for Clostridium difficile-associated disease
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Updated: Jul 18, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
Erik R Dubberke1, Kimberly A Reske, L Clifford McDonald
1Washington University in St. Louis-School of Medicine, Saint Louis, Missouri, USA. edubberk@im.wustl.edu
Abstract:
We conducted a retrospective cohort study to compare Clostridium difficile-associated disease rates determined by C. difficile-toxin assays and International Classification of Diseases, 9th Revision (ICD-9) codes. The correlation between toxin assay results and ICD-9 codes was good (K = 0.72, p<0.01). The sensitivity of the ICD-9 codes was 78% and the specificity was 99.7%.
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