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Updated: Jul 18, 2026

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[Platelet peripheral benzodiazepine receptors in alcoholism]
Abstract:
The peripheral-type benzodiazepine receptor (PBR) is an transmembrane protein, distinct pharmacologically, structurally and functionally from the central-type benzodiazepine receptor. The kinetic binding parameters of the specific PBR ligand, the PK11195, have been evaluated in platelets from 36 male alcoholic patients in relation to 19 healthy sex-matched controls. A significant increase of mean value of platelet PBR density was observed in patients as compared to the controls (4733 +/- 379 and 3358 +/- 242 fmol/mg proteins, p < 0.005). There are no statistically significant changes in the receptor affinity values in the group of patients.
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