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Updated: Jul 18, 2026

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
Expression of Toll-like receptors 2 and 4 in gingivitis and chronic periodontitis
S M Sarah1, S Tamilselvan, S Kamatchiammal
1Department of Periodontics, Sri Ramachandra Medical College & Research Institute, Porur, Chenai.
Abstract:
Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection by oral bacteria. Members of Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharides, and activate signaling pathways that result in immune responses against microbial infections. The aim of the present study was to assess the mRNA expression of TLR-2 and TLR-4 in gingivitis and chronic periodontitis. Gingival tissue samples were collected from patients with chronic periodontitis, gingivitis, and healthy controls. Total RNA was extracted and RT-PCR was done for TLR-2 and TLR-4. The results showed that TLR-2 was significantly increased in gingivitis compared to TLR-4 expression and decreased in chronic periodontitis.
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