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Impact of peripheral arterial disease and acute ischemic stroke

Yasunori Sawayama1, Maki Hamada, Shigeru Otaguro

  • 1Department of General Medicine, Kyushu University Hospital, Fukuoka 812-8582, Japan. sawayama@genmedpr.med.kyushu-u.ac.jp

Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|December 21, 2006
PubMed

Insights

Peripheral arterial disease (PAD) frequently co-occurs with acute ischemic stroke, often asymptomatically. Screening for PAD in stroke patients is recommended to identify this common comorbidity.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Cardiology

Background:

  • Peripheral arterial disease (PAD) is linked to cardiovascular conditions like coronary artery disease and stroke.
  • Limited data exist on the specific relationship between PAD and acute ischemic stroke.

Purpose of the Study:

  • To investigate the association between peripheral arterial disease (PAD) and acute ischemic stroke.
  • To determine the prevalence of PAD in patients experiencing their first ischemic stroke.

Main Methods:

  • A cohort of 101 first-time ischemic stroke patients underwent neuroimaging, carotid ultrasonography, and echocardiography.
  • Peripheral arterial disease (PAD) was assessed in all participants.
  • Clinical data, including serum apoprotein A1 levels and intima-media thickness, were collected.

Main Results:

  • Peripheral arterial disease (PAD) was highly prevalent (80.2%) in ischemic stroke patients.
  • PAD was frequently asymptomatic (51.9%) among affected individuals.
  • Higher serum apoprotein A1 levels and intima-media thickness were observed in patients with PAD.

Conclusions:

  • Peripheral arterial disease (PAD) is a common comorbidity in patients with acute ischemic stroke.
  • Screening for PAD in stroke patients may be clinically important for comprehensive management.
  • Apoprotein A1 levels and admission modified Rankin scale scores are associated with stroke in PAD patients.

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