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Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis
Published on: February 23, 2024
[Role of brain mast cell in multiple sclerosis and Wernicke's encephalopathy]
Jie Pan1, Wei-wei Hu, Zhong Chen
1Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Objective:
Mast cell which is considered to participate in immune response has long been studied. However its true role in center nervous system is still unknown. Recently,mast cell has been found to play an important function during the process of multiple sclerosis and Wernicke's encephalopathy in the brain. Multiple sclerosis is an inflammatory demyelinating disease, and Wernicke's encephalopathy is caused by deficiency of thiamine. Mast cell deteriorates the neuronal damage and the course of diseases by their mediators. Such studies may supply new idea on the therapy of these diseases.
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