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The total synthesis of (+/-)-11-O-debenzoyltashironin
Silas P Cook1, Alessandra Polara, Samuel J Danishefsky
1Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027, USA.
Journal of the American Chemical Society
|December 21, 2006
Abstract:
The total synthesis of the putative non-peptidyl neurotrophic factor 11-O-debenzoyltashironin has been accomplished. The key transformation involves a biomimetic oxidative dearomatization/transannular Diels-Alder sequence that closes the tetracyclic carbon skeleton present in the natural product.
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