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Updated: Aug 16, 2026

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
Published on: February 22, 2018
An antiparallel alpha-helical coiled-coil model system for rapid assessment of side-chain recognition at the
Erik B Hadley1, Samuel H Gellman
1Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA.
Abstract:
Both parallel and antiparallel alpha-helical coiled-coil dimers are common among proteins; however, biophysical scrutiny has focused almost entirely on parallel dimers. We describe the development of a model system that enables efficient and systematic analysis of hydrophobic packing between antiparallel alpha-helices. Our findings reveal significant differences in packing preferences between parallel and antiparallel coiled-coils.
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