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Azythromicin versus amoxicillin-clavulanate in the treatment of acute sinusitis in children

Jasminka Alagić-Smailbegović1, Ediba Saracević, Kamenko Sutalo

  • 1ENT Clinic, University of Sarajevo Clinics Center, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina.

Bosnian Journal of Basic Medical Sciences
|December 21, 2006
PubMed

Insights

Azithromycin and amoxicillin-clavulanate are equally effective for treating acute sinusitis in children. This study found a shorter, single-daily azithromycin regimen matched the efficacy of a longer amoxicillin-clavulanate course.

Area of Science:

  • Pediatric Infectious Diseases
  • Otolaryngology

Background:

  • Acute sinusitis is common in children.
  • Antibiotic selection impacts treatment outcomes and resistance.

Purpose of the Study:

  • To compare the efficacy of azithromycin versus amoxicillin-clavulanate for pediatric acute sinusitis.
  • To evaluate treatment effectiveness using clinical and radiological assessments.

Main Methods:

  • Prospective study of 70 children aged 5-15 years with acute sinusitis.
  • Assessment included clinical exams, nasal/throat cultures, antibiograms, and sinus X-rays.
  • Patients received either azithromycin (10 mg/kg/day for 3 days) or amoxicillin-clavulanate (45 mg/kg/day for 10 days).

Main Results:

  • Azithromycin demonstrated equivalent efficacy to amoxicillin-clavulanate.
  • Both treatments showed comparable outcomes based on follow-up assessments.

Conclusions:

  • Azithromycin offers a convenient and effective alternative for pediatric acute sinusitis treatment.
  • Shorter azithromycin regimens can achieve similar results to longer amoxicillin-clavulanate courses.

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