Related Experiment Video
Updated: Jul 18, 2026

08:02
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis to cow's hair
Suzana Ljubojevic1, Zrinjka Pastar, Jasna Lipozencic
1University Department of Dermatology and Venerology, Zagreb University Hospital Center, 10000 Zagreb, Croatia. suzana.ljubojevic@zg.htnet.hr
Contact Dermatitis
|December 21, 2006
Summary
This study details a farmer's delayed allergy to cow hair, causing skin lesions that improve when away from the farm. Patch testing confirmed cow hair allergy, alongside reactions to common allergens.
Area of Science:
- Dermatology
- Allergology
- Occupational Health
Background:
- Delayed hypersensitivity reactions can manifest as chronic skin conditions in occupational settings.
- Cow hair exposure is a potential, though less common, allergen in agricultural environments.
Observation:
- A 32-year-old female farmer presented with a 5-year history of hand and forearm lesions.
- Symptoms recurred upon entering the cowshed and resolved when she left the farm environment.
Findings:
- Patch testing revealed a positive reaction to cow hair, indicating a delayed-type allergy.
- The patient also showed positive reactions to cobalt chloride, nickel sulfate, and thimerosal.
- Prick tests for inhalant allergens and cow's milk, along with IgE levels, were negative.
Implications:
- Highlights cow hair as a potential occupational allergen causing allergic contact dermatitis.
- Suggests the importance of patch testing with specific environmental allergens in suspected occupational dermatoses.
- Underscores the need for thorough patient history and environmental assessment in diagnosing allergic skin conditions.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions
Overview
Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

