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Skin changes with aging and disease.

R G Jacobson1, F P Flowers

  • 1Division of Dermatology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society
|July 1, 1996
PubMed
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Skin aging involves intrinsic cellular changes and environmental factors like UV radiation, leading to distinct skin attributes and lesions in older individuals. Understanding these processes aids in treatment and prevention.

Area of Science:

  • Dermatology
  • Gerontology
  • Cellular Biology

Background:

  • Skin aging is a complex process influenced by intrinsic and extrinsic factors.
  • Intrinsic aging relates to chronological changes within skin cells and connective tissue.
  • Extrinsic aging, particularly from ultraviolet (UV) irradiation, significantly impacts skin structure and function.

Purpose of the Study:

  • To elucidate the macroscopic and microscopic changes in aging skin.
  • To understand the mechanisms underlying age-related skin alterations.
  • To provide a foundation for treating and preventing age-associated skin conditions.

Main Methods:

  • Review of established dermatological and cellular aging research.
  • Analysis of the combined effects of intrinsic aging and environmental insults.

Related Experiment Videos

  • Correlation of molecular and cellular changes with macroscopic skin manifestations.

    • Main Results:

    • Aging skin exhibits distinct attributes compared to younger skin due to cumulative intrinsic and extrinsic factors.
    • These alterations can manifest as characteristic benign and malignant skin lesions.
    • UV irradiation is a major contributor to extrinsic skin aging.

    Conclusions:

    • A comprehensive understanding of aging mechanisms is crucial for effective dermatological care in older adults.
    • Knowledge of these changes can guide therapeutic strategies for age-related skin diseases.
    • Preventive measures targeting environmental factors like UV exposure are vital for mitigating skin aging.