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SINE elements of Entamoeba dispar
Abdirashid M Shire1, John P Ackers
1Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. shire.abdirashid@mayo.edu
Molecular and Biochemical Parasitology
|December 21, 2006
Summary
Entamoeba dispar contains numerous copies of a novel SINE element (EdSINE1), distinct from those in Entamoeba histolytica. This finding sheds light on the genomic differences between pathogenic and non-pathogenic Entamoeba species.
Area of Science:
- Molecular Parasitology
- Genomics
- Bioinformatics
Background:
- Entamoeba histolytica causes amoebiasis; E. dispar is non-pathogenic.
- E. histolytica has unusual molecular biology, including abundant untranslatable mRNAs from SINE elements (EhSINE1-3).
Purpose of the Study:
- To investigate the presence and characteristics of SINE elements in the E. dispar genome.
- To compare SINE elements between E. dispar and E. histolytica.
Main Methods:
- Genome analysis of E. dispar.
- Identification and characterization of SINE elements (EdSINE1).
- Comparative analysis with E. histolytica SINEs (EhSINE1-3).
Main Results:
- E. dispar genome contains numerous copies of EdSINE1, with conserved 5' and 3' ends but divergent middle sequences compared to EhSINE1.
- Twelve of 18 EdSINE1 copies showed target site duplications, indicating retrotransposition.
- E. histolytica genome lacks EdSINE1 in homologous regions, but contains a single copy identified as EhSINE3.
Conclusions:
- EdSINE1 is a distinct SINE family prevalent in E. dispar.
- Genomic differences in SINE element distribution may contribute to the pathogenic disparity between E. dispar and E. histolytica.
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