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Published on: December 14, 2016
In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis
Poonpilas Hongmanee1, Kamolchanok Rukseree, Benjamas Buabut
1Division of Microbiology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. Poonpilas@hotmail.com
Abstract:
The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.
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