Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic dysfunction in dementia.

L M Allan1, C G Ballard, J Allen

  • 1Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK. louise.allan@ncl.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|December 21, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

To what extent does g impact on conceptual, practical and social adaptive functioning in clinically referred children?

Journal of intellectual disability research : JIDR·2013
Same author

Platelet reactivity changes significantly throughout all trimesters of pregnancy compared with the nonpregnant state: a prospective study.

BJOG : an international journal of obstetrics and gynaecology·2013
Same author

An implementation of a spike-response model with escape noise using an avalanche diode.

IEEE transactions on biomedical circuits and systems·2013
Same author

Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2013
Same author

A prospective study of systemic sclerosis-related digital ulcers: prevalence, location, and functional impact.

Scandinavian journal of rheumatology·2013
Same author

Mechanical testing of lid speculae and relationship to postoperative ptosis.

Eye (London, England)·2013
Same journal

Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Durable fluoropolymer drug-eluting stent versus bare-metal stent for the prevention of intracranial in-stent restenosis.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Correction: <i>How well do plasma Alzheimer's disease biomarkers reflect the CSF amyloid status?</i>

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Correction: <i>First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study</i>.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Correction: <i>Clinical utility of cerebrospinal fluid biomarkers in the evaluation of cognitive impairment: a systematic review and meta-analysis</i>.

Journal of neurology, neurosurgery, and psychiatry·2026
See all related articles

Cardiovascular autonomic dysfunction is present in all common dementias, particularly Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), impacting treatment strategies.

Area of Science:

  • Neurology
  • Cardiology
  • Geriatrics

Background:

  • No prior studies compared autonomic function across Alzheimer's disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD).
  • Autonomic dysfunction is a potential comorbidity in neurodegenerative diseases.

Purpose of the Study:

  • To compare cardiovascular autonomic function in patients with AD, VAD, DLB, and PDD against elderly controls.
  • To determine the prevalence of orthostatic hypotension and autonomic neuropathies using established classifications.

Main Methods:

  • Utilized Ewing's battery of autonomic function tests and power spectral analysis of heart rate variability.
  • Assessed 39 AD, 30 VAD, 30 DLB, 40 PDD patients, and 38 elderly controls.

Related Experiment Videos

Main Results:

  • Significant differences in autonomic dysfunction severity were observed across dementia types.
  • Parkinson's disease dementia (PDD) and DLB exhibited considerable autonomic dysfunction, with PDD showing more severe impairment than DLB.
  • Alzheimer's disease (AD) showed minimal autonomic impairment, primarily orthostatic hypotension, while VAD had limited dysfunction.

Conclusions:

  • Autonomic dysfunction is prevalent in all common dementias, notably PDD and DLB.
  • The degree of autonomic dysfunction varies significantly between dementia subtypes.
  • Findings have implications for clinical management and treatment of patients with dementia.