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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Related Experiment Video

Updated: Jul 18, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

Parkinson's disease and driving ability.

Rajiv Singh¹, Brian Pentland, John Hunter

¹Department of Neurorehabilitation, Astley Ainslie Hospital, 133 Grange Loan, Edinburgh EH9 2HL, UK. rajiv.singh@lpct.scot.nhs.uk

Journal of Neurology, Neurosurgery, and Psychiatry

|December 21, 2006

Summary

Most individuals with Parkinson's disease (PD) can continue driving safely, though some may need automatic transmissions or vehicle modifications. Clinical assessments effectively predict driver safety in PD patients.

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Last Updated: Jul 18, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

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Published on: June 17, 2013

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Area of Science:

Neurology
Transportation Safety
Gerontology

Background:

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting motor function.
Driving is a crucial activity for independence in aging populations.
Assessing driving safety in individuals with PD is essential for public health and personal autonomy.

Purpose of the Study:

To identify driving problems in individuals with Parkinson's disease (PD).
To determine if clinical features or tests can predict driver safety in PD patients.

Main Methods:

154 individuals with PD underwent driving assessments.
Assessments included clinical tests, reaction time tests on a rig, and in-car driving tests.

Main Results:

66% of individuals with PD could continue driving; 32% required automatic transmission or car modifications.
Driving ability was predicted by disease severity (Hoehn and Yahr stage 3), age, comorbidities (especially dementia), disease duration, reaction time, and driving test scores.
Drug treatment levels and driving history length did not correlate with driving safety.

Conclusions:

The majority of individuals with PD maintain driving safety, often with adaptations.
A combination of clinical evaluations and on-road assessments reliably determines driving safety.
Clinical correlates can predict driving outcomes, aiding in decision-making for PD patients' driving status.