Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neoadjuvant chemotherapy for cervical carcinoma.

M G Rabinovich1, G Focaccia, R Ferreyra

  • 1Service of Oncology, Hospital Provincial Neuquen, Argentina.

Obstetrics and Gynecology
|October 1, 1991
PubMed
Summary

This study evaluated neoadjuvant chemotherapy for advanced cervical cancer. The regimen showed limited efficacy, with few objective regressions and a high progression rate, questioning its value.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A histomorphometric study of osteocytic lacunae in interradicular bone with periodontal disease.

Acta odontologica latinoamericana : AOL·2004
Same author

Double modulation of 5-fluorouracil by trimetrexate and leucovorin in patients with advanced colorectal carcinoma.

American journal of clinical oncology·2004
Same author

Neoadjuvant chemotherapy with ifosfamide, cisplatin, and vinorelbine in advanced squamous cell carcinoma of the cervix.

American journal of clinical oncology·2000
Same author

Immunohistochemical analysis of the activation of NF-kappaB and expression of associated cytokines and adhesion molecules in human models of allergic inflammation.

The Journal of pathology·1999
Same author

Biochemical modulation of 5-fluorouracil by methotrexate in patients with advanced gastric carcinoma.

American journal of clinical oncology·1998
Same author

Biomodulation with sequential intravenous IFN-alpha2b and 5-fluorouracil as second-line treatment in patients with advanced colorectal cancer.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·1998

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Clinical Chemotherapy

Background:

  • Locally advanced cervical carcinoma requires effective treatment strategies.
  • Neoadjuvant chemotherapy aims to improve outcomes before definitive therapy.
  • Evaluating novel chemotherapy regimens is crucial for treatment optimization.

Purpose of the Study:

  • To assess the efficacy and toxicity of a neoadjuvant chemotherapy regimen in patients with locally advanced cervical carcinoma.
  • To determine the objective response rate and progression rate of the studied chemotherapy combination.
  • To evaluate the safety profile of the neoadjuvant chemotherapy regimen.

Main Methods:

  • A prospective study involving 33 previously untreated patients with locally advanced cervical carcinoma.

Related Experiment Videos

  • Administration of cisplatin, vincristine, and bleomycin chemotherapy for three cycles every 10 days.
  • Definitive radiation therapy (external and intracavitary) administered after chemotherapy.
  • Assessment of treatment response and toxicity by a multidisciplinary team.

    • Main Results:

    • No complete response was observed in 31 fully evaluable patients.
    • Partial response rate was 23% (7 patients), with 58% (18 patients) showing no change.
    • Disease progression was observed in 19% (6 patients), indicating limited efficacy.
    • Reported toxicities included nausea, vomiting, alopecia, hyperthermia, neurotoxicity, and anemia, generally mild to moderate.

    Conclusions:

    • The evaluated neoadjuvant chemotherapy regimen demonstrated a low number of objective regressions.
    • A significant rate of disease progression was observed, suggesting limited benefit.
    • The regimen, at this dosage and schedule, is of doubtful value for neoadjuvant treatment in locally advanced cervical carcinoma.