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Updated: Jul 18, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
Sensitivity of rabies virus to type I interferon is determined by the phosphoprotein gene
Kenta Shimizu1, Naoto Ito, Makoto Sugiyama
1The United Graduate School of Veterinary Sciences, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan.
Abstract:
The growth of a virulent strain of fixed rabies virus, Nishigahara, in mouse neuroblastoma NA cells treated with type I interferon (IFN) was compared with that of a derivative avirulent strain, Ni-CE. Nishigahara strain was slightly sensitive to IFN treatment but still grew more efficiently than did Ni-CE strain in IFN-treated NA cells. Furthermore, a virulent chimeric virus with the phosphoprotein gene from Nishigahara strain in the Ni-CE genome was less sensitive to IFN treatment than was Ni-CE strain, indicating that the IFN sensitivity is determined by the phosphoprotein gene of the virus.
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