Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monokines in growth and development.

K C Klasing1, B J Johnstone

  • 1Department of Avian Sciences, University of California, Davis 95616.

Poultry Science
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molt dampens pro-inflammatory cytokine production during the acute phase response to lipopolysaccharide in the domestic chicken (Gallusdomesticus).

Developmental and comparative immunology·2025
Same author

The effects of vaccination with keyhole limpet hemocyanin or oral administration of Salmonella enterica serovar Enteritidis on the growth performance of immunoglobulin knockout chickens.

Poultry science·2019
Same author

Space allowance influences individually housed Holstein male calves' age at feed consumption, standing behaviors, and measures of immune resilience before and after step-down weaning.

Journal of dairy science·2019
Same author

Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide.

Poultry science·2017
Same author

Space allowance influences individually housed Holstein bull calf innate immune measures and standing behaviors after castration at 3 weeks of age.

Journal of dairy science·2017
Same author

Liver mitochondrial oxygen consumption and proton leak kinetics in broilers supplemented with dietary copper or zinc following coccidiosis challenge.

Journal of animal physiology and animal nutrition·2016

Immune system stimulation triggers metabolic shifts away from growth. Monokines redirect nutrients to support immunity, impacting muscle, metabolism, and nutrient distribution.

Area of Science:

  • Immunology
  • Metabolic Physiology
  • Cell Biology

Background:

  • Immune system activation involves monokines like interleukin-1, tumor necrosis factor, and interleukin-6.
  • These cytokines are released by monocyte-macrophage lineage cells upon recognizing immunogens.
  • Monokines mediate a homeorhetic response, altering nutrient partitioning.

Purpose of the Study:

  • To elucidate the metabolic and cellular changes induced by immune system stimulation.
  • To understand how monokines influence nutrient allocation and growth processes.
  • To investigate the effects of specific monokines on cell differentiation.

Main Methods:

  • The study describes observed metabolic and cellular alterations.
  • It infers mechanisms based on known cytokine functions.

Related Experiment Videos

  • It references the roles of specific monokines in cellular processes.

    • Main Results:

    • Immune stimulation decreases skeletal muscle accretion via altered protein synthesis and degradation.
    • Basal metabolic rate increases, leading to higher energy utilization.
    • Dietary amino acids are preferentially used for gluconeogenesis and energy, not muscle growth.
    • Liver synthesizes acute-phase proteins, and minerals (iron, zinc, copper) are redistributed.
    • Cartilage and bone accretion are impaired, and hormone release (insulin, glucagon, corticosterone) is affected.
    • Tumor necrosis factor inhibits myoblast and adipocyte differentiation, while myelomonocytic growth factor promotes granulocyte differentiation.

    Conclusions:

    • Monokines orchestrate a metabolic shift away from growth towards immune defense.
    • These cytokines significantly impact nutrient utilization, energy expenditure, and tissue accretion.
    • Monokines play a crucial role in regulating cell differentiation, influencing immune cell development and suppressing other cell lineages.