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Updated: Jul 18, 2026

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
07:17

Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex

Published on: August 2, 2021

CD95 (APO-1/Fas)-associating signalling proteins

M E Peter1, F C Kischkel, S Hellbardt

  • 1German Cancer Research Center, Tumor Immunology Program, Heidelberg, Germany.

Cell Death and Differentiation
|April 1, 1996
PubMed

Insights

The CD95 receptor triggers cell death signaling. Recent research identifies interacting proteins, clarifying the CD95 death pathway and receptor crosstalk at a molecular level.

Area of Science:

  • Cell biology
  • Molecular biology
  • Immunology

Background:

  • The CD95 receptor (also known as APO-1/Fas) is crucial for initiating apoptosis across various tissues.
  • CD95 is a member of the nerve growth factor/tumor necrosis factor (NGF/TNF) receptor superfamily, requiring ligand-induced trimerization for signal transduction.

Purpose of the Study:

  • To review recent advancements in understanding the proximal signal transduction mechanism of the CD95 receptor.
  • To elucidate the molecular basis of the CD95-mediated death pathway and receptor interactions.

Main Methods:

  • Literature review focusing on recent research findings.
  • Analysis of studies involving the cloning of CD95-interacting proteins.
  • Examination of in vivo identification of ligand-dependent CD95-associating proteins.

Main Results:

  • Numerous proteins interacting with CD95 and related receptors have been identified.
  • In vivo studies have revealed proteins that associate with CD95 in a ligand-dependent manner.
  • These findings provide a molecular framework for understanding the CD95 death pathway.

Conclusions:

  • The identification of interacting proteins is key to delineating the CD95 death pathway.
  • Understanding these molecular interactions explains crosstalk among NGF/TNF receptor superfamily members.
  • This knowledge advances the comprehension of apoptosis regulation and immune system signaling.

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