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Updated: Jul 18, 2026
07:17
Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex
Published on: August 2, 2021
CD95 (APO-1/Fas)-associating signalling proteins.
M E Peter1, F C Kischkel, S Hellbardt
1German Cancer Research Center, Tumor Immunology Program, Heidelberg, Germany.
Cell Death and Differentiation
|April 1, 1996
Summary
The CD95 receptor triggers cell death signaling. Recent research identifies interacting proteins, clarifying the CD95 death pathway and receptor crosstalk at a molecular level.
Area of Science:
- Cell biology
- Molecular biology
- Immunology
Background:
- The CD95 receptor (also known as APO-1/Fas) is crucial for initiating apoptosis across various tissues.
- CD95 is a member of the nerve growth factor/tumor necrosis factor (NGF/TNF) receptor superfamily, requiring ligand-induced trimerization for signal transduction.
Purpose of the Study:
- To review recent advancements in understanding the proximal signal transduction mechanism of the CD95 receptor.
- To elucidate the molecular basis of the CD95-mediated death pathway and receptor interactions.
Main Methods:
- Literature review focusing on recent research findings.
- Analysis of studies involving the cloning of CD95-interacting proteins.
- Examination of in vivo identification of ligand-dependent CD95-associating proteins.
Main Results:
- Numerous proteins interacting with CD95 and related receptors have been identified.
- In vivo studies have revealed proteins that associate with CD95 in a ligand-dependent manner.
- These findings provide a molecular framework for understanding the CD95 death pathway.
Conclusions:
- The identification of interacting proteins is key to delineating the CD95 death pathway.
- Understanding these molecular interactions explains crosstalk among NGF/TNF receptor superfamily members.
- This knowledge advances the comprehension of apoptosis regulation and immune system signaling.
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