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Published on: May 31, 2022
Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients
L B Pupim1, P J Flakoll, T A Ikizler
1Department of Medicine, Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Objective:
To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.
Design:
Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.
Setting:
General Clinical Research Center at Vanderbilt University Medical Center.
Subjects:
Five chronic hemodialysis (CHD) patients.
Interventions:
Intra-dialytic parenteral nutrition (IDPN) with or without exercise.
Results:
Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2+/-3.1% per day versus 17.7+/-1.9% per day, P<0.05).
Conclusion:
Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.
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