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Updated: Jul 18, 2026
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A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Skull metastasis from hepatocellular carcinoma
1Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Acta Neurochirurgica
|December 21, 2006
Summary
Skull metastases from hepatocellular carcinoma (HCC) are rare but should be considered. Early diagnosis of these rare cranial tumors is essential for effective treatment and improved patient outcomes.
Area of Science:
- Oncology
- Neurosurgery
- Radiology
Background:
- Skull metastases commonly arise from lung, breast, and prostate cancers.
- Metastases to the skull from hepatocellular carcinoma (HCC) are infrequently reported in medical literature.
Observation:
- A 46-year-old male with HCC presented with a painless left frontal skull mass.
- Radiography and CT revealed a large osteolytic lesion with a soft tissue component.
- Surgical resection via left frontal craniectomy achieved complete tumor removal.
Findings:
- Histological examination confirmed the cranial mass as a metastasis from HCC.
- The patient experienced an uneventful recovery with no neurological deficits post-surgery.
Implications:
- Increased survival for HCC patients may lead to a rise in distant metastases, including rare cranial sites.
- Skull metastasis from HCC should be included in the differential diagnosis for patients with unexplained cranial masses and osteolytic defects.
