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Updated: Jul 18, 2026
Multifocal Electroretinograms
Published on: December 4, 2011
Multifocal ERG findings in carriers of X-linked retinoschisis
Linda S Kim1, William Seiple, Gerald A Fishman
1Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Eye and Ear Infirmary, 1855 West Taylor Street, Chicago, IL 60612-7234, USA.
Purpose:
To determine whether retinal dysfunction in obligate carriers of X-linked retinoschisis (XLRS) could be observed in local electroretinographic responses obtained with the multifocal electroretinogram (mfERG).
Methods:
Nine obligate carriers of XLRS (mean age, 46.2 years) were examined for the study. Examination of each carrier included an ocular examination and mfERG testing. For the mfERG, we used a 103-scaled hexagonal stimulus array that subtended a retinal area of approximately 40 degrees in diameter. The amplitudes and implicit times in each location for the mfERG were compared with the corresponding values determined for a group of 34 normally-sighted, age-similar control subjects.
Results:
Mapping of 103 local electroretinographic response amplitudes and implicit times within a central 40 degrees area with the mfERG showed regions of reduced mfERG amplitudes and delayed implicit times in two of nine carriers.
Conclusions:
The mfERG demonstrated areas of retinal dysfunction in two carriers of XLRS. When present, retinal dysfunction was evident in the presence of a normal-appearing fundus. Multifocal ERG testing can be useful for identifying some carriers of XLRS.
