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Updated: Jul 18, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
Published on: January 7, 2018
[Current options of insulin resistence correction in patients with metabolic syndrome]
Aim:
To study thiasolidindion drug pioglitazone for efficacy in metabolic syndrome (MS).
Material And Methods:
Twenty patients with MS were examined at baseline and after 12 week therapy with pioglitazone. The examination included estimation of fasting and postprandial glycemia, insulin resistance index, HOMA-IR index, HbAlc, lipid profile, microalbuminuria (MAU), blood pressure, endothelium-related vasodilation.
Results:
Pioglitazone therapy for 12 weeks significantly reduced HbAlc, fasting and postprandial glycemia, insulinemia, HOMA-IR, improved blood lipid spectrum, reduced visceral obesity.
Conclusion:
Positive effects were also achieved on blood pressure, MAU and endothelium-related vasodilation.
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