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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

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Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
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Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
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Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Alzheimer Disease l: Introduction01:29

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

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Orienteering as a Tool for Cognitive Research: An Implementation Guide
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Published on: November 29, 2024

Improving cognition and function through exercise intervention in Alzheimer's disease.

Fang Yu1, Ann M Kolanowski, Neville E Strumpf

  • 1University of Minnesota School of Nursing, Minneapolis, MN, USA. yuxxx244@umn.edu

Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing
|December 22, 2006
PubMed
Summary

Cognitive function, particularly executive function, significantly impacts daily activities in Alzheimer's disease (AD). Aerobic exercise may enhance both cognitive and functional abilities in individuals with AD.

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Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
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Orienteering as a Tool for Cognitive Research: An Implementation Guide
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Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

Area of Science:

  • Neuroscience
  • Gerontology
  • Cognitive Science

Background:

  • Cognitive impairment is a hallmark of Alzheimer's disease (AD), profoundly affecting daily functioning.
  • Understanding the relationship between specific cognitive domains and functional decline is crucial for effective interventions.

Purpose of the Study:

  • To analyze how cognitive abilities influence functional capacity in individuals with AD.
  • To explore the potential of aerobic exercise interventions for improving cognitive and functional outcomes in AD.

Main Methods:

  • An integrative literature review was conducted, analyzing studies from 1980 to 2006.
  • Searches combined keywords related to Alzheimer's disease, dementia, cognitive impairment, function, and activities of daily living.

Main Results:

  • Global cognition is often assessed, assuming a hierarchical decline in function in AD.
  • Specific cognitive domains, especially executive functioning, show a greater impact on function than memory.
  • Aerobic exercise may positively influence cognitive and functional capacities in AD by affecting neuropathological processes.

Conclusions:

  • Executive functioning is a key cognitive domain for understanding and potentially improving function in AD.
  • Aerobic exercise presents a promising avenue for enhancing cognitive and functional capacities in individuals with AD.