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Related Experiment Video

Updated: Jul 18, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent.

Patricia Fulco¹, Richard P Wenzel

¹Virginia Commonwealth University, Department of Internal Medicine, Richmond, VA, USA. pfulco@mcvh-vcu.edu

Expert Review of Anti-Infective Therapy

|December 22, 2006

Summary

Ramoplanin is a novel antibiotic effective against gram-positive bacteria, including vancomycin-resistant enterococci. Clinical trials show promise for preventing infections and treating Clostridium difficile.

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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

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Last Updated: Jul 18, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

Area of Science:

Microbiology
Pharmacology
Infectious Diseases

Background:

Ramoplanin is a novel antibiotic targeting gram-positive bacteria by inhibiting peptidoglycan synthesis.
It acts by binding to lipid II, a crucial intermediate in bacterial cell wall formation.
Ramoplanin has received US FDA fast-track designation for enterococcal infections and Clostridium difficile treatment.

Purpose of the Study:

To evaluate the efficacy of ramoplanin in preventing enterococcal infections in carriers.
To assess ramoplanin's effectiveness in treating Clostridium difficile colitis.
To determine the clinical utility of ramoplanin in suppressing target organism carriage.

Main Methods:

Phase II trials were conducted, including a double-blind, placebo-controlled study in vancomycin-resistant enterococci carriers.
Equivalence of ramoplanin and vancomycin was assessed for C. difficile colitis treatment.
Minimum inhibitory concentrations (MIC90s) were determined against various gram-positive organisms.

Main Results:

Ramoplanin demonstrated potent activity with MIC90s <= 1.0 microg/ml against tested gram-positive bacteria.
A Phase II trial showed proof of concept for ramoplanin in suppressing target organism carriage.
Ramoplanin proved equivalent to vancomycin in treating C. difficile colitis.

Conclusions:

Ramoplanin exhibits significant potential as a therapeutic agent against challenging gram-positive pathogens.
Further Phase III trials are necessary to establish its definitive clinical value and role in therapy.
The antibiotic's ability to suppress organism carriage in the GI tract and nares requires further investigation.