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Updated: Jul 18, 2026

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Pseudomyxoma peritonei
R M Smeenk1, V J Verwaal, F A N Zoetmulder
1Department of Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Pseudomyxoma peritonei (PMP) is a rare, high-mortality condition. Early recognition and complete cytoreduction via surgery and hyperthermic chemotherapy offer promising treatment outcomes.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Pseudomyxoma peritonei (PMP) is a rare malignancy with high mortality if untreated.
- Early diagnosis of PMP is crucial for improving patient prognosis.
- Understanding PMP pathogenesis and diagnostic methods is essential.
Purpose of the Study:
- To highlight the importance of early recognition of PMP.
- To discuss the essential knowledge of pathogenesis and diagnostic tools for PMP.
- To present the current effective treatment strategy for PMP.
Main Methods:
- Review of PMP pathogenesis and diagnostic modalities.
- Focus on cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Main Results:
- Complete cytoreduction is the primary goal in PMP treatment.
- Combined modality treatment (cytoreductive surgery + HIPEC) shows high efficiency.
- This approach is increasingly adopted globally with positive outcomes.
Conclusions:
- Early diagnosis and understanding of PMP are critical.
- Cytoreductive surgery with HIPEC is an effective treatment for PMP.
- This combined approach is becoming the standard of care for PMP.
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