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Multifocal Electroretinograms

Multifocal Electroretinograms

Published on: December 4, 2011

Abnormal multifocal electroretinogram (mfERG) in ethambutol toxicity.

Randy H Kardon¹, Mary C Morrisey, Andrew G Lee

¹Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.

Seminars in Ophthalmology

|December 22, 2006

Summary

Ethambutol toxicity can cause visual loss by affecting retinal elements, not just the optic nerve. Multifocal electroretinography (mfERG) revealed abnormal retinal function in patients with ethambutol-induced vision problems.

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Published on: December 4, 2011

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Area of Science:

Ophthalmology
Neuroscience
Toxicology

Background:

Ethambutol is a first-line medication for tuberculosis.
Optic neuropathy is a known side effect of ethambutol.
Visual loss in ethambutol toxicity is typically attributed to optic nerve damage.

Observation:

This study reports on two patients experiencing bilateral visual loss attributed to ethambutol toxicity.
Multifocal electroretinography (mfERG) was performed to assess retinal function in these patients.

Findings:

mfERG revealed both diffuse and central field loss in both patients.
These findings suggest retinal dysfunction contributes to the visual field loss observed.
Abnormal mfERG waveforms indicate impaired function of retinal elements.

Implications:

Ethambutol toxicity may impact retinal function beyond the optic nerve.
mfERG can be a valuable tool in diagnosing and understanding ethambutol-induced visual impairment.
Further research is needed to elucidate the precise mechanisms of ethambutol's retinal toxicity.