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Related Experiment Videos

Brain connectivity related to working memory performance.

Michelle Hampson1, Naomi R Driesen, Pawel Skudlarski

  • 1Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520-8042, USA. michelle.hampson@yale.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 22, 2006
PubMed
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The posterior cingulate cortex (PCC) and medial frontal gyrus/ventral anterior cingulate cortex (MFG/vACC) are functionally connected during rest and working memory tasks. This connectivity predicts cognitive performance, suggesting a role in facilitating tasks rather than disengaging.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • Default Mode Network (DMN) regions, including the posterior cingulate cortex (PCC) and medial frontal gyrus/ventral anterior cingulate cortex (MFG/vACC), are typically observed to decrease activity during cognitive tasks.
  • It has been hypothesized that these DMN regions disengage during cognitive effort.

Purpose of the Study:

  • To investigate the functional connectivity between the PCC and MFG/vACC during a working memory task and at rest.
  • To determine if this functional connectivity is associated with working memory performance.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to measure signal levels in the PCC and MFG/vACC.
  • Temporal correlations in BOLD signal between these regions were analyzed during a working memory task and a resting state.

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  • Correlation analyses were performed between functional connectivity strength and working memory task performance.

    • Main Results:

    • The PCC and MFG/vACC demonstrated significant functional connectivity during both the working memory task and rest.
    • The strength of functional connectivity between the PCC and MFG/vACC was positively correlated with working memory task performance.
    • This positive correlation was observed during both task performance and rest.

    Conclusions:

    • The PCC and MFG/vACC may form a network that facilitates or monitors cognitive performance, rather than simply disengaging during tasks.
    • Individual differences in the resting-state functional connectivity between these regions might predict cognitive abilities relevant to working memory.