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Updated: Jul 18, 2026

Mouse Abdominal Aortic Aneurysm Model Induced by Perivascular Application of Elastase
Published on: February 11, 2022
Increased angiogenesis at the site of abdominal aortic aneurysm rupture
Edward Choke1, Gillian W Cockerill, Joseph Dawson
1Department of Vascular Surgery, 4th Floor St. James Wing, St. George's Hospital, Blackshaw Rd., London SW17 0QT.
Abstract:
Abdominal aortic aneurysm (AAA) rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic aneurysm rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the aneurysm rupture edge compared with paired aneurysm anterior sac. Further investigations into the role of angiogenesis in aneurysm rupture may open novel therapeutic avenues to prevent aneurysm rupture.
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