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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

Integrating cell-signalling pathways with NF-kappaB and IKK function.

Neil D Perkins1

  • 1College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK. n.d.perkins@dundee.ac.uk

Nature Reviews. Molecular Cell Biology
|December 22, 2006
PubMed
Summary
This summary is machine-generated.

Nuclear factor kappa B (NF-κB) and inhibitor of NF-κB kinase (IKK) pathways are crucial for immune responses and inflammation. Their crosstalk with other signaling networks determines cell fate and contributes to diseases like cancer.

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NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Immunology

Background:

  • Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins are key regulators of immune responses, inflammation, and cell death.
  • Dysregulation of NF-κB/IKK pathways is implicated in various human diseases, notably cancer.

Purpose of the Study:

  • To explore the intricate crosstalk between NF-κB/IKK signaling pathways and other cellular networks.
  • To understand how this integration influences cellular decision-making processes and outcomes.

Main Methods:

  • Analysis of molecular interactions within signaling networks.
  • Investigating the integration of NF-κB/IKK pathways with other cell-signaling cascades.

Main Results:

  • Identified multiple mechanisms integrating NF-κB and IKK activity with other signaling pathways.
  • Demonstrated that this crosstalk is a critical determinant of NF-κB and IKK activation consequences.

Conclusions:

  • The interplay between NF-κB/IKK and other signaling networks is essential for regulating cellular processes.
  • Understanding this crosstalk is vital for deciphering disease mechanisms and developing therapeutic strategies.