Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Runx1-Snx9 axis drives the pathological secretion of mitochondrial-derived vesicles to activate cGAS-STING signaling in acute pancreatitis.

Journal of nanobiotechnology·2026
Same author

MZB1 Modulates Inflammatory Severity in Severe Acute Pancreatitis through an IgA-Associated Intestinal Barrier Axis.

Inflammation·2026
Same author

Sex-dependent impact of <i>Il6</i> deficiency in Parkinson's disease mice.

Genes & diseases·2026
Same author

Extracellular vesicles derived from hADSCs rescue acute pancreatitis by carrying <i>p</i>-STK3 to regulate Treg differentiation.

iScience·2026
Same author

Highly sensitive analysis of N-glycans via derivatization with quinoline hydrazide reagents.

Analytica chimica acta·2026
Same author

Prediction of malignancy and metastasis of thyroid cancer by combined feature sets through advanced machine learning.

BMC medical informatics and decision making·2026

Related Experiment Video

Updated: Jul 18, 2026

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
07:54

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Published on: May 10, 2015

Reduced aggression in mice lacking GABA transporter subtype 1.

Guo-Xiang Liu1, Shuai Liu, Guo-Qiang Cai

  • 1Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Model Organism Research Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Journal of Neuroscience Research
|December 22, 2006
PubMed
Summary

The GABA transporter subtype 1 (GAT1) is crucial for regulating aggression. Mice lacking or with reduced GAT1 showed less aggressive behavior, indicating GAT1

More Related Videos

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

Electrophoretic Delivery of &#x3B3;-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Related Experiment Videos

Last Updated: Jul 18, 2026

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors
07:54

Applying Stereotactic Injection Technique to Study Genetic Effects on Animal Behaviors

Published on: May 10, 2015

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
07:51

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors

Published on: November 14, 2014

Electrophoretic Delivery of &#x3B3;-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Pharmacology

Background:

  • The brain's GABAergic system plays a role in aggression.
  • GABA transporter subtype 1 (GAT1) regulates GABAergic activity.
  • GAT1 dysfunction may link to pathological aggression.

Purpose of the Study:

  • Investigate the role of GAT1 in aggressive behavior.
  • Examine the effects of GAT1 inhibition and GABA(A) receptor antagonism on aggression.
  • Assess the relationship between GAT1, aggression, and testosterone levels.

Main Methods:

  • Utilized GAT1 knockout (GAT1-/-), heterozygous (GAT1+/-), and wild-type (GAT1+/+) mice.
  • Conducted resident-intruder tests in home cage and neutral arena settings.
  • Administered GAT1 inhibitor tiagabine and GABA(A) receptor antagonist bicuculline to wild-type mice.
  • Monitored circadian activity patterns and measured testosterone concentrations.

Main Results:

  • GAT1-/- and GAT1+/- mice exhibited significantly reduced aggressive behavior compared to GAT1+/+ mice.
  • Tiagabine decreased aggression, while bicuculline increased aggression in GAT1+/+ mice.
  • GAT1-/- mice showed increased overall activity but normal circadian patterns.
  • Reduced testosterone levels were observed in GAT1-/- mice, but not in tiagabine-treated GAT1+/+ mice.

Conclusions:

  • GAT1 is a significant regulator of aggressive behavior in mice.
  • GAT1 dysfunction may influence testosterone secretion.
  • Targeting GAT1 presents a potential therapeutic avenue for aggression-related disorders.