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Updated: Jul 18, 2026

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Published on: August 19, 2021
Clear-cell endocervical adenocarcinoma in a 19-year-old woman
Jimmie Stewart1, Kristen Bevans-Wilkins, Changhong Ye
1Cytopathology Section, Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA. jj.stewart@hosp.wisc.edu
Abstract:
The incidence of adenocarcinoma of the cervix is increasing within the US, but this diagnostic category is not typically associated with teenaged patients. A report on a case of a 19-year-old woman, with no history of diethylbestrol exposure in uteri, diagnosed with clear-cell endocervical adenocarcinoma is made. Malignant glandular cells were detected on both conventional and Thin Prep gynecologic tests with histologic confirmation. Human papilloma virus (HPV) high-risk type results were negative in this particular case. The patient's unremarkable medical and sexual history prompted us to review the diagnostic criteria and pathogenesis of the disease.
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