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Nasal glial heterotopy in childhood: a case report highlighting the morphological and immunohistochemical features
Paras Kathuria1, Shilpi Agarwal
1Department of Pathology, L. H. M. C., New Delhi. drparas25@rediffmail.com
Abstract:
We present a case of a 5 months old infant who presented with difficulty in breathing and a visible intranasal swelling. Clinical examination revealed a reddish mass medial to the middle turbinate in the left nasal cavity. MRI was done and a provisional diagnosis of nasal glioma was suggested. The mass was surgically excised and sent for histopathology which showed it to be comprising of astrocytes and neuroglial fibers intermixed with a fibrovascular connective tissue stroma. The presence of Glial fibrillary acid protein (GFAP) confirmed the presence of glial tissue.
Insights
A rare nasal glioma, a congenital nasal mass, was diagnosed in a 5-month-old infant presenting with breathing difficulties. Surgical removal and histopathology confirmed the glial tissue, aiding in understanding this rare condition.
Area of Science:
- Pediatric Surgery
- Neuropathology
- Congenital Malformations
Background:
- Nasal gliomas are rare congenital tumors, typically presenting as a midline nasal mass.
- Early diagnosis and surgical intervention are crucial for optimal outcomes in infants.
Observation:
- A 5-month-old infant presented with dyspnea and an observable intranasal swelling.
- Clinical examination identified a reddish mass in the left nasal cavity, medial to the middle turbinate.
- Magnetic Resonance Imaging (MRI) suggested a nasal glioma.
Findings:
- Surgical excision of the intranasal mass was performed.
- Histopathological analysis revealed glial tissue composed of astrocytes and neuroglial fibers within a fibrovascular stroma.
- Glial Fibrillary Acidic Protein (GFAP) staining confirmed the glial origin of the tumor.
Implications:
- This case highlights the importance of considering nasal glioma in the differential diagnosis of infant nasal masses.
- Successful surgical resection confirms the efficacy of surgical management for pediatric nasal gliomas.
- Understanding the histopathological characteristics, including GFAP expression, is vital for accurate diagnosis and management.
