Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transduction01:16

Transduction

934
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
934
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.8K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.8K
Hypersensitivities01:30

Hypersensitivities

5.9K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
5.9K
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

9.4K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
9.4K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

1.1K
In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.1K
Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

4.6K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure-induced high-temperature superconductivity in ternary Y-Zr-H compounds.

Physical chemistry chemical physics : PCCP·2023
Same author

Identification of Potential Key Genes and Prognostic Biomarkers of Lung Cancer Based on Bioinformatics.

BioMed research international·2023
Same author

Effect of heat and hypoxia stress on mitochondrion and energy metabolism in the gill of hard clam.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP·2023
Same author

Elongated Riboflavin-Producing Shewanella oneidensis in a Hybrid Biofilm Boosts Extracellular Electron Transfer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023
Same author

Reflectance confocal microscopy findings of clear cell papulosis and histopathological correlation.

Postepy dermatologii i alergologii·2023
Same author

The Complete Mitochondrial Genome and Gene Arrangement of the Enigmatic Scaphopod <i>Pictodentalium vernedei</i>.

Genes·2023
Same journal

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

ACS chemical biology·2026
Same journal

Synthesis and Characterization of the Spectroscopic and Imaging Utilities of Two Indole-Based Cyan Fluorescent Nucleoside Analogues.

ACS chemical biology·2026
Same journal

Indole Ring Expansion and Rearrangement-Enabled Quinoline Scaffold Formation in the Biosynthesis of the Antitumor Monoterpene Indole Alkaloid Camptothecin.

ACS chemical biology·2026
Same journal

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain.

ACS chemical biology·2026
Same journal

Development of Next-Generation Fluoroacetamidine-Containing Activity-Based Probes for the Selective Labeling of the Protein Arginine Deiminases (PADs).

ACS chemical biology·2026
Same journal

Spectroelectrochemical Insight into Reaction Mechanisms of Cell-Penetrating Peptides on Charged Membrane Surfaces.

ACS chemical biology·2026
See all related articles

Related Experiment Videos

Evolving sensitivity.

Hao Song1, Lingchong You

  • 1Department of Biomedical Engineering and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA.

ACS Chemical Biology
|December 23, 2006
PubMed
Summary
This summary is machine-generated.

Engineering novel gene circuits offers broad applications. Directed evolution is a key strategy for optimizing these circuits and their components, complementing rational design.

Related Experiment Videos

Area of Science:

  • Synthetic biology
  • Genetic engineering

Background:

  • Novel gene circuits are crucial for advancing biology, engineering, and medicine.
  • Optimizing gene circuit function is essential for their practical application.

Discussion:

  • Directed evolution provides a powerful, complementary approach to rational design for enhancing gene circuits.
  • This strategy accelerates the development of complex genetic control systems.

Key Insights:

  • Gene circuit engineering enables the creation of systems with tailored biological functions.
  • Directed evolution effectively optimizes both entire gene circuits and individual circuit elements.

Outlook:

  • Further development of directed evolution techniques will expand the capabilities of synthetic biology.
  • Optimized gene circuits hold potential for transformative applications in therapeutics and biotechnology.