Related Experiment Video
Updated: Jul 18, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Marek's disease virus: lytic replication, oncogenesis and control.
Keith W Jarosinski1, B Karsten Tischer, Sascha Trapp
1Cornell University, Department of Microbiology and Immunology, College of Veterinary Medicine, Ithaca, NY 14853, USA. kwj4@cornell.edu
Expert Review of Vaccines
|December 23, 2006
Summary
Marek's disease (MD), caused by MD virus (MDV), is a significant poultry concern. This review details MDV genes like Meq and vTR involved in oncogenesis and discusses modern strategies for improved vaccination and control.
Area of Science:
- Veterinary Virology
- Oncology
- Poultry Health
Background:
- Marek's disease (MD) is a significant economic concern in the poultry industry, driven by increasingly virulent strains of the MD virus (MDV).
- MDV is a lymphotropic alphaherpesvirus causing lymphomas, neurological signs, and wasting in chickens.
- Despite comprehensive vaccination, virulent MDV strains have emerged, necessitating further research into disease mechanisms and control.
Purpose of the Study:
- To review MDV genes implicated in oncogenesis, focusing on those initiating or maintaining tumor development.
- To summarize current vaccination and control strategies against Marek's disease.
- To explore the potential of modern molecular biology in enhancing future MD control strategies.
Main Methods:
- Literature review of scientific publications on Marek's disease, MDV, oncogenesis, and control strategies.
- Analysis of studies identifying specific MDV genes and their roles in cellular transformation (e.g., Meq, vTR).
- Evaluation of current and emerging vaccination and disease management approaches.
Main Results:
- Several MDV genes, including Meq (transforming protein) and vTR (maintaining transformed cells), are crucial for oncogenesis.
- MDV gene products involved in early replication modulate transformation risk.
- Current vaccination strategies face challenges due to emerging virulent strains.
Conclusions:
- Understanding MDV's genetic mechanisms of oncogenesis is key to developing effective control measures.
- Molecular biology offers promising avenues for improving MDV vaccines and diagnostics.
- Integrated strategies combining genetic insights and advanced biotechnology are essential for future MD control.
Related Concept Videos
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:20Viral Replication: Lytic Cycle
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:28Rabies
Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...