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Published on: April 1, 2019
Transforming growth factor-beta1 polymorphisms in patients with brucellosis: an association between codon 10 and 25
A Rafiei1, M Hajilooi, R J Shakib
1Department of Immunology and Microbiology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran. Rafiei1710@gmail.com
Abstract:
This study examined the association between transforming growth factor (TGF)-beta1 polymorphisms and brucellosis. The TGF-beta1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-beta1 codons 10 C and 25 G were significantly higher among patients than among controls, as was that of TGF-beta1 codon 10 C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-beta1 gene might contribute to the development of brucellosis.
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