[An etiological study of eosinophilic granuloma]

By means of the proof for the enzyme phenol oxidase (PO; EC 1.14.18.1) was investigated, whether the eosinophilic granuloma correspond to a cell mediated immunological defence reaction. The method allowed to determine the eosinophils rapidly and surely and give an overview on the frequency and distribution of these cells. By electron microscopy was Langerhans-cells identified in close contact to many eosinophils. Their granula shows manifold changes in their structure. The eosinophilic granuloma is a cell mediated defence reaction approximate to the type of a delayed hypersensitivity.