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Updated: Jul 18, 2026
10:21
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Lung large cell carcinoma producing granulocyte-colony-stimulating factor
Sachiko Hasegawa1, Takashi Suda, Koji Negi
1Division of General Thoracic Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. hsachiko@fujita-hu.ac.jp
The Annals of Thoracic Surgery
|December 23, 2006
Summary
Tumors producing granulocyte-colony-stimulating factor (G-CSF) are increasingly reported, often in lung cancer patients. This case details successful resection and chemotherapy for lung carcinoma producing G-CSF, with no recurrence after nearly three years.
Area of Science:
- Oncology
- Endocrinology
Background:
- Increasing reports of tumors producing granulocyte-colony-stimulating factor (G-CSF).
- Majority of these tumors are associated with lung cancer.
- G-CSF production by tumors can lead to paraneoplastic syndromes.
Observation:
- A case of lung carcinoma presenting with G-CSF production.
- The patient was treated with surgical resection and chemotherapy.
- Clinical course and outcome were monitored.
Findings:
- Successful surgical resection of the G-CSF-producing lung carcinoma.
- Adjuvant chemotherapy was administered post-surgery.
- The patient achieved a favorable outcome with no evidence of recurrence.
Implications:
- Highlights the importance of recognizing G-CSF-producing lung tumors.
- Demonstrates the efficacy of multimodal treatment (surgery + chemotherapy).
- Suggests a potential for long-term survival in select cases of G-CSF-producing lung carcinoma.
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