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Biocatalysis for pharmaceutical intermediates: the future is now.
David J Pollard1, John M Woodley
1Process Research, Merck Research Laboratories, Merck and Co, PO Box 2000, Rahway, NJ 07065, USA.
Trends in Biotechnology
|December 23, 2006
Summary
Biocatalysis is a key tool for pharmaceutical development, offering high optical purity for complex molecules. Micro-scale technology and integrated disciplines accelerate catalyst screening and process development for greener, more productive chemistry.
Area of Science:
- Biocatalysis and Chemical Process Development
Background:
- Biocatalysis is increasingly vital in process chemistry, complementing traditional methods like chemocatalysis.
- The pharmaceutical industry requires rapid development cycles and high optical purity for complex chiral compounds.
Purpose of the Study:
- To review strategies for successful biocatalysis implementation in the pharmaceutical industry.
- To highlight advancements enabling biocatalysis to meet industry demands for speed and purity.
Main Methods:
- Utilizing micro-scale technology for high-throughput screening of biocatalysts.
- Integrating biology, engineering, and chemistry disciplines for efficient process development.
- Leveraging recombinant technology for expanding biocatalytic capabilities.
Main Results:
- Micro-scale technology facilitates rapid catalyst screening and process optimization.
- Interdisciplinary collaboration enhances the successful application of biocatalysis.
- Recombinant technology is expanding the scope of achievable chemistries.
Conclusions:
- Biocatalysis, enhanced by micro-scale technology and interdisciplinary integration, is meeting pharmaceutical industry demands.
- Future developments in recombinant technology will broaden biocatalysis applications and catalyst design.
- Continued advancements promise greener and more productive biocatalytic processes.
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