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Updated: Jul 18, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Anetoderma associated with primary antiphospholipid syndrome.
Elemir Macedo de Souza1, Patrícia Erica Christofoletti Daldon, Maria Letícia Cintra
1Department of Dermatology, State University of Campinas--UNICAMP, São Paulo, Brazil.
Journal of the American Academy of Dermatology
|December 23, 2006
Summary
A man developed anetodermic lesions and deep vein thrombosis. This case highlights a potential link between antiphospholipid antibodies and these conditions.
Area of Science:
- Dermatology
- Hematology
- Immunology
Background:
- Anetodermic lesions are characterized by localized loss of elastic tissue in the dermis.
- Antiphospholipid antibodies are associated with an increased risk of thrombosis.
Observation:
- A 34-year-old man presented with a 7-year history of nodules that evolved into anetodermic lesions on his face, neck, torso, and arms.
- Following the onset of these skin lesions, the patient developed deep vein thrombosis in his right arm and leg.
Findings:
- Circulating antiphospholipid antibodies were detected in the patient's blood.
- The clinical presentation suggests a potential association between anetodermic lesions and antiphospholipid syndrome.
Implications:
- This case may broaden the understanding of the clinical manifestations of antiphospholipid syndrome.
- Further research is warranted to explore the relationship between dermatological conditions and thrombotic events in the context of antiphospholipid antibodies.
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