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Related Experiment Videos

Bronchial typical carcinoid tumors.

Uliano Morandi1, Christian Casali, Giulio Rossi

  • 1Division of Thoracic Surgery, Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia, Modena, Italy. morandi.uliano@unimo.it

Seminars in Thoracic and Cardiovascular Surgery
|December 23, 2006
PubMed
Summary
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Typical carcinoid lung tumors are low-grade neuroendocrine tumors. Surgical resection offers excellent survival rates, with local recurrence manageable by surgery, but distant metastases have a poor prognosis.

Area of Science:

  • Oncology
  • Pulmonology
  • Pathology

Background:

  • Typical carcinoid tumors are classified as low-grade neuroendocrine tumors of the lung.
  • These slow-growing tumors can metastasize regionally and, rarely, extrathoracically.
  • Symptoms often stem from bronchial compression or obstruction, and paraneoplastic syndromes may occur.

Purpose of the Study:

  • To review the characteristics, diagnosis, treatment, and prognosis of typical carcinoid lung tumors.
  • To emphasize the role of surgical resection in achieving curative intent.
  • To discuss the implications of staging and metastasis on patient outcomes.

Main Methods:

  • Review of current WHO classification for lung tumors.
  • Description of diagnostic modalities including bronchoscopic biopsy, CT, and somatostatin receptor scintigraphy.

Related Experiment Videos

  • Analysis of treatment options: endoscopic laser resection versus surgical resection.
  • Evaluation of prognostic factors and survival rates post-surgery.

    • Main Results:

    • Complete surgical resection is the primary curative therapy for most patients.
    • Parenchyma-sparing resections are preferred when feasible.
    • Excellent overall survival (5-year rate: 87-100%) and low recurrence rates (2-11%) are observed after surgery.
    • N-status and resection type do not appear to significantly impact prognosis.

    Conclusions:

    • Surgical resection provides excellent outcomes for typical carcinoid lung tumors.
    • Local recurrence is treatable with surgery, but distant metastases carry a poor prognosis.
    • Accurate preoperative staging is crucial for optimal management planning.