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Ketamine potentiates 5-HT3 receptor-mediated currents in rabbit nodose ganglion neurones
J A Peters1, H M Malone, J J Lambert
1Department of Pharmacology & Clinical Pharmacology, Ninewells Hospital & Medical School, University of Dundee.
British Journal of Pharmacology
|July 1, 1991
Abstract:
The interaction of ketamine with the 5-HT3 receptor of rabbit nodose ganglion neurones is described. Ketamine (3-30 microM) enhanced 5-HT3 receptor-mediated currents recorded under voltage-clamp conditions. This action did not appear to be related to the known effect of ketamine of inhibiting 5-HT uptake.