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Related Experiment Videos

Ancient noncoding elements conserved in the human genome.

Byrappa Venkatesh1, Ewen F Kirkness, Yong-Hwee Loh

  • 1Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673. mcbbv@imcb.a-star.edu.sg

Science (New York, N.Y.)
|December 23, 2006
PubMed
Summary
This summary is machine-generated.

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Comparing elephant shark and human genomes revealed twice as many conserved noncoding elements (CNEs). These ancient CNEs likely regulate gene expression in jawed vertebrates.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Comparative Genomics

Background:

  • Cartilaginous fishes (Chondrichthyes) are a basal lineage of jawed vertebrates, diverging from the ancestor of humans and teleost fishes over 530 million years ago.
  • Understanding conserved elements between divergent vertebrate groups aids in identifying fundamental biological regulatory mechanisms.

Purpose of the Study:

  • To identify conserved noncoding elements (CNEs) between cartilaginous fishes and humans.
  • To explore the evolutionary history and potential regulatory functions of CNEs in vertebrates.

Main Methods:

  • Generated approximately 1.4x genome sequence coverage for the elephant shark (Callorhinchus milii).
  • Performed comparative genomic analysis between the elephant shark genome and the human genome.

Related Experiment Videos

  • Identified conserved noncoding elements (CNEs) by comparing genomic sequences.

    • Main Results:

    • The elephant shark genome comparison yielded twice the number of CNEs compared to previous teleost fish-human genome comparisons.
    • Identified ancient vertebrate-specific CNEs shared between elephant shark and human genomes.

    Conclusions:

    • The elephant shark genome provides a valuable resource for identifying ancient conserved elements in vertebrates.
    • Ancient vertebrate-specific CNEs are likely crucial for regulating gene expression across diverse vertebrate lineages.