Diagnostic accuracy of multislice CT angiography in peripheral arterial disease

A systematic search of the PubMed and Medline databases of English literature was performed to determine the diagnostic accuracy of multislice computed tomographic (CT; MSCT) angiography in peripheral arterial disease (PAD) compared with digital subtraction angiography (DSA). Studies comparing MSCT angiography with DSA in peripheral vascular disease were included, and the diagnostic value of MSCT angiography in terms of sensitivity, specificity, and diagnostic accuracy was compared and analyzed. Ten studies (19 comparisons) met the criteria and were included for analysis. The pooled sensitivity, specificity, and accuracy rates were 92%, 91%, and 91%, respectively, at all arterial levels; 92%, 94%, and 93%, respectively, at aortoiliac arteries; 96%, 85%, and 92%, respectively, at femoropopliteal arteries; and 91%, 85%, and 87%, respectively, at infrapopliteal arteries. A significant difference was found in the sensitivity of MSCT angiography in PAD between four-slice CT and 16-slice CT, between aortoiliac and femoropopliteal arterial segments, and between femoropopliteal and infrapopliteal arterial segments (P<.05). This review demonstrates that MSCT angiography has a high diagnostic value and could be a reliable alternative to DSA in the diagnosis of PAD.