Two cases of subacute thyroiditis presenting in pregnancy

Area of Science:

• Endocrinology
• Obstetrics
• Reproductive Medicine

Background:

• Subacute thyroiditis (SAT) is a rare cause of thyrotoxicosis during pregnancy.
• Untreated thyrotoxicosis poses risks to fetal development, including prematurity and congenital malformations.

Observation:

• Two cases of first-trimester SAT are presented: one mild and one severe.
• The severe case showed significant laboratory and ultrasound findings consistent with SAT.

Findings:

• The severe SAT case was successfully managed with prednisolone, with benefits outweighing potential teratogenic risks.
• The mild SAT case resolved spontaneously with conservative management and no pharmacological intervention.

Implications:

• Laboratory and ultrasound findings are crucial for guiding SAT treatment decisions in pregnancy.
• Individualized treatment approaches for SAT in pregnancy ensure healthy maternal and fetal outcomes, as evidenced by full-term deliveries in both cases.